The BioComputational Group in CNIO is a multidisciplinary group and a part of the Structural Biology and Biocomputing Programme. The group includes people with background in experimental biology, computer science and mathematics, interested in understanding the chimeric RNAs and associated proteins in eukaryotic cells.
Prof.Alfonso Valencia Principal Investigator, The Program Director Spanish National Cancer Research Centre (CNIO), Madrid, Spain Dr.Milana Frenkel-Morgenstern Staff Scientist Spanish National Cancer Research Centre (CNIO), Madrid, SpainMilana has analyzed the data on thousands of chimeric transcripts and proteins in different organisms, designed experiments and produced the major Bioinformatics analysis of chimeras.
The visualization of chimeras was done in collaboration with Mark Rogers and Asa Ben-Hur from the Department of Computer Sciences, Colorado State University. We utilized the SpliceGrapher software developed in the group of Prof.Asa Ben-Hur.
Prof.Asa Ben-Hur The department of Computer Sciences The Colorado State University, USAThe DNA search was done in collaboration with Dr.Jaime Prilusky from the Bioinformatics Unit, Weizmann Institute of Science. The RNA-seq mapping of chimeric transcripts was done in collaboration with Dr.Vincent Lacroix from UCBL, Lyon, France. We utilized the GEM software developed in the group of Prof.Roderic Guigo from the Center of Genomic Regulation, Barcelona. The mySQL database and the Perl scripts were done in collaboration with Dr.Alessandro Gorohovski from the National Technical University of Ukraine (KPI).
Dr.Jaime Prilusky Bioinformatics Unit Weizmann Institute of Science, Rehovot, Israel Dr.Vincent Lacroix Baobab Group UCBL, Lyon, France Prof.Roderic Guigo Genome Informatics Research Laboratory Center Genomic Regulation, Barcelona, Spain Dr.Alessandro Gorohovski Department of Ecology National Technical University of Ukraine (KPI), Kiev, UkraineThe proteomic analysis was conducted in collaboration with Dr.Yishai Levin, head of the Proteomics Unit at the Israeli Center for Personalized Medicine, Weizmann Institute of Science, Israel. The Proteomics Unit specializes in quantitative Proteomics in both basic biological research as well as biomedical applications.